Far-red dibenzo[a,j]perylene-8,16-dione dyes as fluorescent enzyme substrates and tags for biomolecules

Abstract

The synthesis of fluorescent 2,10-derivatives of the title chromophore are described. The substituents contain amino-reactive N-hydroxysuccinimde ester and thiol-reactive iodoacetamide groups for attachment to biomolecules. A phosphate derivative was also prepared as an enzyme substrate.