Journal article
ALTERATIONS IN ERYTHROCYTE BAND 3 ORGANIZATION INDUCED BY THE PHOTOSENSITIZER, HEMATOPORPHYRIN DERIVATIVE
S Beaton, RA McPherson, L Tilley
Photochemistry and Photobiology | Published : 1995
Abstract
Abstract— Photosensitization of erythrocytes in the presence of hematoporphyrin derivative causes cross‐linking of membrane proteins. This cross‐linking is associated with partial lysis of the cells and an increased susceptibility to heat‐induced membrane fragmentation. The effect of photosensitization on the organization of erythrocyte band 3 was monitored using the technique of time‐resolved phosphorescence anisotropy. Band 3 rotational diffusion was somewhat restricted upon photooxidation, indicating aggregation of this major integral membrane protein. Copyright © 1995, Wiley Blackwell. All rights reserved