Journal article
A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease
LA Deinema, AJ Vingrys, CY Wong, DC Jackson, HR Chinnery, LE Downie
Ophthalmology | ELSEVIER SCIENCE INC | Published : 2017
Abstract
Purpose To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED). Design Randomized, double-masked, placebo-controlled clinical trial. Participants This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements. Methods Participants received 1 of the 3 interventions: placebo (olive oil 1500 mg/day), krill oil (945 mg/day eicosapentaenoic acid [EPA], + 510 mg/day docosahexaenoic acid [DHA]), or fish oil (1000 mg/day EP..
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Grants
Funding Acknowledgements
L.E.D.: Grant - Rebecca L. Cooper Medical Foundation, Sydney, New South Wales, Australia (2015) and a University of Melbourne Early Career Researcher grant, Parkville, Victoria, Australia (2015). The sponsors had no role in the design or conduct of this research.