Journal article

Definition for Rheumatoid Arthritis Erosions Imaged with High Resolution Peripheral Quantitative Computed Tomography and Interreader Reliability for Detection and Measurement

Cheryl Barnabe, Dominique Toepfer, Hubert Marotte, Ellen-Margrethe Hauge, Andrea Scharmga, Roland Kocijan, Sebastian Kraus, Stephanie Boutroy, Georg Schett, Kresten Krarup Keller, Joost de Jong, Kathryn S Stok, Stephanie Finzel

The Journal of Rheumatology | J RHEUMATOL PUBL CO | Published : 2016

Abstract

OBJECTIVE: High-resolution peripheral quantitative computed tomography (HR-pQCT) sensitively detects erosions in rheumatoid arthritis (RA); however, nonpathological cortical bone disruptions are potentially misclassified as erosive. Our objectives were to set and test a definition for pathologic cortical bone disruptions in RA and to standardize reference landmarks for measuring erosion size. METHODS: HR-pQCT images of metacarpophalangeal joints of RA and control subjects were used in an iterative process to achieve consensus on the definition and reference landmarks. Independent readers (n = 11) applied the definition to score 58 joints and measure pathologic erosions in 2 perpendicular mul..

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University of Melbourne Researchers