Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity
JP Moodie, KS Stok, R Mueller, TL Vincent, SJ Shefelbine
Osteoarthritis and Cartilage | ELSEVIER SCI LTD | Published : 2011
OBJECTIVE: Alterations in joint mechanics can cause osteoarthritis, which results in degeneration of both cartilage and bone tissue. The objective of this work is to measure changes in the laxity of the mouse knee joint after destabilisation of the medial meniscus (DMM) and to visualise and quantify the resulting three-dimensional changes in the bone and cartilage. METHODS: Skeletally mature C57Bl6 male mice underwent DMM surgery in the right leg. Animals were sacrificed immediately 0 weeks (n=15), 4 weeks (n=11) or 8 weeks (n=12) after surgery. For the 0-week group, the anterior-posterior (AP) and varus-valgus laxity of the DMM limb were compared to the contralateral limb. For 4 and 8-week ..View full abstract
ESPRC Case Studentship supported JPM. Royal Society Grant funded the first portion of this work. The Idea League Scholarship facilitated collaboration between labs. All study sponsors had no involvement in the study or the writing of the manuscript.