Genome-wide analysis identifies 12 loci influencing human reproductive behavior

N Barban; R Jansen; R De Vlaming; A Vaez; JJ Mandemakers; FC Tropf; X Shen; JF Wilson; DI Chasman; IM Nolte; V Tragante; SW Van Der Laan; JRB Perry; A Kong; TS Ahluwalia; E Albrecht; L Yerges-Armstrong; G Atzmon; K Auro; K Ayers; A Bakshi; D Ben-Avraham; K Berger; A Bergman; L Bertram; LF Bielak; G Bjornsdottir; MJ Bonder; L Broer; M Bui; C Barbieri; A Cavadino; JE Chavarro; C Turman; MP Concas; HJ Cordell; G Davies; P Eibich; N Eriksson; T Esko; J Eriksson; F Falahi; JF Felix; MA Fontana; L Franke; I Gandin; AJ Gaskins; C Gieger; EP Gunderson; X Guo; C Hayward; C He; E Hofer; H Huang; PK Joshi; S Kanoni; R Karlsson; S Kiechl; A Kifley; A Kluttig; P Kraft; V Lagou; C Lecoeur; J Lahti; R Li-Gao; PA Lind; T Liu; E Makalic; C Mamasoula; L Matteson; H Mbarek; PF McArdle

Journal article

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

N Barban, R Jansen, R De Vlaming, A Vaez, JJ Mandemakers, FC Tropf, X Shen, JF Wilson, DI Chasman, IM Nolte, V Tragante, SW Van Der Laan, JRB Perry, A Kong, TS Ahluwalia, E Albrecht, L Yerges-Armstrong, G Atzmon, K Auro, K Ayers Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2016

DOI: 10.1038/ng.3698

Abstract

© 2016 Nature America, Inc. part of Springer Nature, All Rights reserved. The genetic architecture of human reproductive behavior - age at first birth (AFB) and number of children ever born (NEB) - has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and ..

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University of Melbourne Researchers

Minh Bui Author

Enes Makalic Author

Daniel Schmidt Author Melbourne School of Population and Global Health

Grants

Awarded by Medical Research Council

Funding Acknowledgements

For full acknowledgments, see the Supplementary Note. Funding to lead this consortium was provided by grants awarded to M.C.M.: ERC Consolidator Grant SOCIOGENOME (615603), a Dutch Science Foundation (NWO) grant (VIDI grant 452-10-012), a UK ESRC/NCRM SOCGEN grant (ES/N011856/1), the European Union's FP7 Families And Societies project (320116), and the Wellcome Trust ISSF and John Fell Fund. M.d.H. was supported by grants from the Swedish Research Council (2015-03657) and the Swedish Heart-Lung Foundation (20140543). Research was carried out in collaboration with the Social Science Genetic Association Consortium (SSGAC), with funding from the US National Science Foundation (EAGER: 'Workshop for the Formation of a Social Science Genetic Association Consortium'), a Supplementary grant from the National Institutes of Health Office of Behavioral and Social Science Research, the Ragnar Soderberg Foundation (E9/11), the Swedish Research Council (421-2013-1061), the Jan Wallander and Tom Hedelius Foundation, an ERC Consolidator Grant (647648 EdGe), the Pershing Square Fund of the Foundations of Human Behavior and the NIA/NIH through grants P01-AG005842, P01-AG005842-20S2, P30-AG012810 and T32-AG000186-23 to NBER and R01-AG042568-02 to the University of Southern California. X.S. was supported by a grant from the Swedish Research Council (537-2014-371). We thank X. Ding for research assistance, N. Pirastu, K. Coward and L. Layman for valuable comments, and the University of Oxford Advanced Research Computing (ARC) facility (http://dx.doi.org/10.5281/zenodo.22558). This research has been conducted using the UK Biobank Resource.