Synaptic Zn2 and febrile seizure susceptibility
Christopher A Reid, Michael S Hildebrand, Saul A Mullen, Joanne M Hildebrand, Samuel F Berkovic, Steven Petrou
BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2017
Zn2+ , the second most prevalent trace element in the body, is essential for supporting a wide range of biological functions. While the majority of Zn2+ in the brain is protein-bound, a significant proportion of free Zn2+ is found co-localized with glutamate in synaptic vesicles and is released in an activity-dependent manner. Clinical studies have shown Zn2+ levels are significantly lower in blood and cerebrospinal fluid of children that suffer febrile seizures. Likewise, investigations in multiple animal models demonstrate that low levels of brain Zn2+ increase seizure susceptibility. Recent work provides human genetic evidence that disruption of brain Zn2+ homeostasis at the level of the ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
This work was supported by National Health and Medical Research Council (NHMRC) Program grant (10915693) to S. F. B., S. P. and C. A. R., Research Fellowship to S. P., a Postdoctoral Training Fellowship to S. A. M. and a Career Development Fellowship (1063799) to M. S. H. C. A. R. is supported by a Dowd Fellowship. J. M. H. acknowledges funding from NHMRC Project grant APP1105023. The Florey Institute of Neuroscience and Mental Health is supported by Department of Health, State Government of Victoria infrastructure funds.