Journal article
Macrolactam analogues of macrolide natural products
HM Hügel, AT Smith, MA Rizzacasa
Organic and Biomolecular Chemistry | ROYAL SOC CHEMISTRY | Published : 2016
DOI: 10.1039/c6ob02149b
Abstract
The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.
Grants
Funding Acknowledgements
We thank the Australian Research Council for financial support.