Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis
CD Marth, SM Firestone, LY Glenton, GF Browning, ND Young, N Krekeler
Veterinary Research | Biomed Central | Published : 2016
© 2016 The Author(s). Infectious endometritis is a major cause of reduced pregnancy rates in horses. The objectives of this study were to establish a timeline of the innate immune response in the uterus of healthy horses and to investigate the oestrous cycle effect on this. Endometrial biopsies were collected from five horses before and at 3, 12, 24, 48 and 72 h after inoculation of Escherichia coli, once in oestrus and once in dioestrus. They were analysed by quantitative real-time PCR, microbiology and histology. Neutrophil numbers increased from very low levels in the absence of inflammation to severe neutrophilia 3 h after inoculation. The concentrations of mRNAs for Toll-like receptor (..View full abstract
Related Projects (1)
This work was supported by funds from an Early Career Research Grant provided by the University of Melbourne. Neil Young holds an NHMRC Career Development Fellowship.