Journal article
MOZ and BMI1 act synergistically to maintain hematopoietic stem cells
BN Sheikh, D Metcalf, AK Voss, T Thomas
Experimental Hematology | ELSEVIER SCIENCE INC | Published : 2017
Abstract
Chromatin plays a central role in maintaining hematopoietic stem cells and during their stepwise differentiation. Although a large number of histone modifications and chromatin-modifying enzymes have been identified, how these act in concert to produce specific phenotypic outcomes remains to be established. MOZ (KAT6A) is a lysine acetyltransferase and enhances transcription at target gene loci. In contrast, the Polycomb group protein BMI1 (PCGF4) is part of the transcriptionally repressive PRC1 complex. Despite their opposing effects on transcription, MOZ and BMI1 regulate biological systems in a similar manner. MOZ and BMI1 are required for the development of transplantable HSCs, for restr..
View full abstractGrants
Awarded by Australian government's National Health and Medical Research Council (NHMRC)
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
We thank Professor M van Lohuizen for allowing us to use the Bmi1 knockout mice. We thank R. Cobb, N. L. Downer, F. Dabrowski, L. Di Rago, and the WEHI FACS laboratory for excellent technical support. This work was funded by the Australian government's National Health and Medical Research Council (NHMRC) through Project Grants 1008699, 1010851, 1030704, and 1084509; through Research Fellowships 1003435 (TT) and AKV 575512 and 1081421 (AKV); and through the Independent Research Institutes Infrastructure Support (IRIIS) Scheme and also through a Victorian State Government Operational Infrastructure Support (OIS) grant.