Journal article

Improved Auditory Nerve Survival with Nanoengineered Supraparticles for Neurotrophin Delivery into the Deafened Cochlea

Andrew K Wise, Justin Tan, Yajun Wang, Frank Caruso, Robert K Shepherd

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2016

Abstract

Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf patients. In normal hearing cochleae the SGNs depend on endogenous neurotrophins secreted by sensory cells in the organ of Corti for survival. SGNs gradually degenerate following deafness and consequently there is considerable interest in developing clinically relevant strategies to provide exogenous neurotrophins to preserve SGN survival. The present study investigated the safety and efficacy of a drug delivery system for the cochlea using nanoengineered silica supraparticles. In the present study we delivered Brain-derived neurotrophic factor (BDNF) over a perio..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Awarded by National Institutes of Health (USA)


Funding Acknowledgements

This work was funded by National Health and Medical Research Council Project Grant APP1005071 and APP1064375, Australian Research Council under the Australian Laureate Fellowship scheme (120100030), and National Institutes of Health (USA) HHS-N-263-2007-00053-C.