Journal article
Shortened telomere length in bipolar disorder: A comparison of the early and late stages of disease
FM Barbé-Tuana, MM Parisi, BS Panizzutti, GR Fries, LK Grun, FT Guma, F Kapczinski, M Berk, CS Gama, AR Rosa
Revista Brasileira De Psiquiatria | ASSOC BRASILEIRA PSIQUIATRIA | Published : 2016
Abstract
Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study received financial support from the Ministerio da Ciencia, Tecnologia e Inovacao (MCT)/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)-Universal (grants 479305/2009-9, 473515/2013-0, and 443526/2014-1), CNPq Produtividade em Pesquisa (304443/2014-0), and Ciencias sem Fronteiras (CSF) (40.00032/2012-0). FMB-T and BSP received fellowships from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES). MMP and GRF received a fellowship from CNPq. BSP received a scholarship from CAPES/CSF and CNPq/GD. MB is supported by the National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1059660). ARR is grateful for the support provided by L'Oreal Brasil, Academia Brasileira de Ciencias, and the UNESCO National Commission For Women in Science.