Journal article
Evidence for Cooperative Selection of Axons for Myelination by Adjacent Oligodendrocytes in the Optic Nerve
Darragh M Walsh, Tobias D Merson, Kerry A Landman, Barry D Hughes
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
The cellular mechanisms that regulate the topographic arrangement of myelin internodes along axons remain largely uncharacterized. Recent clonal analysis of oligodendrocyte morphologies in the mouse optic nerve revealed that adjacent oligodendrocytes frequently formed adjacent internodes on one or more axons in common, whereas oligodendrocytes in the optic nerve were never observed to myelinate the same axon more than once. By modelling the process of axonal selection at the single cell level, we demonstrate that internode length and primary process length constrain the capacity of oligodendrocytes to myelinate the same axon more than once. On the other hand, probabilistic analysis reveals t..
View full abstractRelated Projects (2)
Grants
Awarded by Australian Research Council Discovery Project
Awarded by Australian Research Council
Funding Acknowledgements
This research was supported by an Australian Research Council Discovery Project (DP140100339) and the Melbourne Neuroscience Institute Interdisciplinary Seed Funding Scheme. Dr. Tobias Merson was supported by an Australian Research Council Future Fellowship (FT150100207). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This research was supported by an Australian Research Council Discovery Project (DP140100339) and the Melbourne Neuroscience Institute Interdisciplinary Seed Funding Scheme. Dr. Tobias Merson was supported by an Australian Research Council Future Fellowship (FT150100207). We thank Dr. Laura Dumas for helpful discussions on her data, Dr. William R. Holmes for valuable discussions and Dr. James McCaw and Dr. James Osborne for useful comments on the manuscript.