Real-time Image-guided Adaptive-predictive Prostate Radiotherapy using Rectal Diameter as a Predictor of Motion
R Oates, A Brown, A Tan, F Foroudi, M Lim Joon, M Schneider, A Herschtal, T Kron
Comparative Haematology International | ELSEVIER SCIENCE LONDON | Published : 2017
AIMS: To investigate a relationship between maximum rectal diameter (MRD) on pre-treatment cone beam computed tomography (CBCT) and intra-fraction prostate motion, in the context of an adaptive image-guided radiotherapy (IGRT) method. MATERIALS AND METHODS: The MRD was measured on 2125 CBCTs from 55 retrospective patient datasets and related to prostate displacement from intra-fraction imaging. A linear regression model was developed to determine a threshold MRD associated with a high probability of small prostate displacement. Standard and reduced adaptive margin plans were created to compare rectum and bladder normal tissue complication probability (NTCP) with each method. RESULTS: A per-p..View full abstract
The authors would like to acknowledge the support of the Department of Radiation Oncology at the Peter MacCallum Cancer Centre and the Townsville Cancer Centre. Special thanks to Christina Finlason for contouring guidance.