Journal article

Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury

Bridgette D Semple, Shilpi Dixit, Sandy R Shultz, Wah Chin Boon, Terence J O'Brien



Chronic social behavior problems after pediatric traumatic brain injury (TBI) significantly contribute to poor quality of life for survivors. Using a well-characterized mouse model of early childhood TBI, we have previously demonstrated that young brain-injured mice develop social deficits by adulthood. As biological sex may influence both normal and aberrant social development, we here evaluated potential sex differences in post-TBI psychosocial deficits by comparing the behavior of male and female mice at adulthood (8 weeks post-injury). Secondly, we hypothesized that pediatric TBI would influence neuronal morphology identified by Golgi-Cox staining in the hippocampus and prefrontal cortex..

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Awarded by CJ Martin Overseas Early Career Fellowship from National Health and Medical Research Council of Australia

Funding Acknowledgements

BDS was supported by a CJ Martin Overseas Early Career Fellowship (#1052505) from the National Health and Medical Research Council of Australia, and an Early Career Researcher Grant from the University of Melbourne. The authors thank A/Prof. Ann Turnley for providing access to the controlled cortical impactor device, and Victorian State Government Infrastructure Support.