Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury
Bridgette D Semple, Shilpi Dixit, Sandy R Shultz, Wah Chin Boon, Terence J O'Brien
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2017
Chronic social behavior problems after pediatric traumatic brain injury (TBI) significantly contribute to poor quality of life for survivors. Using a well-characterized mouse model of early childhood TBI, we have previously demonstrated that young brain-injured mice develop social deficits by adulthood. As biological sex may influence both normal and aberrant social development, we here evaluated potential sex differences in post-TBI psychosocial deficits by comparing the behavior of male and female mice at adulthood (8 weeks post-injury). Secondly, we hypothesized that pediatric TBI would influence neuronal morphology identified by Golgi-Cox staining in the hippocampus and prefrontal cortex..View full abstract
Related Projects (1)
DELINEATING THE CONTRIBUTION OF INFLAMMATION TO LONG-TERM NEURODEGENERATION, NEUROPSYCHIATRIC OUTCOMES AND SEIZURE SUSCEPTIBILITY FOLLOWING TRAUMATIC INJURY TO THE IMMATURE BRAIN
Epilepsy is a common, debilitating consequence of brain injury in children, however little is known about factors which trigger its developm..
Awarded by CJ Martin Overseas Early Career Fellowship from National Health and Medical Research Council of Australia
BDS was supported by a CJ Martin Overseas Early Career Fellowship (#1052505) from the National Health and Medical Research Council of Australia, and an Early Career Researcher Grant from the University of Melbourne. The authors thank A/Prof. Ann Turnley for providing access to the controlled cortical impactor device, and Victorian State Government Infrastructure Support.