Journal article
Tau imaging with [18F]THK-5351 in progressive supranuclear palsy
A Ishiki, R Harada, N Okamura, N Tomita, CC Rowe, VL Villemagne, K Yanai, Y Kudo, H Arai, S Furumoto, M Tashiro, K Furukawa
European Journal of Neurology | WILEY-BLACKWELL | Published : 2017
DOI: 10.1111/ene.13164
Abstract
Background and purpose: Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative conditions. Aggregates of the microtubule-binding protein, tau, are one of the most important pathogenic molecules in neurodegenerative disorders. Progressive supranuclear palsy (PSP) is characterized by the deposition of tau proteins in some specific area such as the basal ganglia and brainstem. We tried to detect tau lesions in the brains of living patients with PSP with a novel positron emission tomography (PET) tracer, [18F]THK-5351, which we have recently developed. Methods: Paraffin-embedded brain sections of the pati..
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Awarded by GE Healthcare
Funding Acknowledgements
The costs of publication of this article were defrayed in part by the payment of page charges. Therefore, and solely to indicate this fact, this article is hereby marked 'advertisement' in accordance with 18 United States Code (USC) section 1734. This study was supported by research funds from GE Healthcare, Sumitomo Electric Industries, Ltd Group CSR Foundation, Industrial Technology Research grant program of the NEDO in Japan (09E51025a), Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare of Japan, grant-in-aid for Scientific Research (B) (15H04900), grant-in-aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control) (26117003), grant-in-aid for Young Scientists (B) (15K19767), and grant-in-aid for JSPS Fellows and Japan Advanced Molecular Imaging Program (J-AMP) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.