Journal article

Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain

Sherie Ma, Craig M Smith, Anna Blasiak, Andrew L Gundlach

BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2017

Abstract

Relaxin-3 is a member of a superfamily of structurally-related peptides that includes relaxin and insulin-like peptide hormones. Soon after the discovery of the relaxin-3 gene, relaxin-3 was identified as an abundant neuropeptide in brain with a distinctive topographical distribution within a small number of GABAergic neuron populations that is well conserved across species. Relaxin-3 is thought to exert its biological actions through a single class-A GPCR - relaxin-family peptide receptor 3 (RXFP3). Class-A comprises GPCRs for relaxin-3 and insulin-like peptide-5 and other peptides such as orexin and the monoamine transmitters. The RXFP3 receptor is selectively activated by relaxin-3, where..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (Australia)


Awarded by Polish Ministry of Science and Higher Education


Awarded by National Science Centre (Poland)


Awarded by EU


Funding Acknowledgements

Research by the authors is supported by research grants from the National Health and Medical Research Council (Australia) (1024885, 1067522, 1106330 ALG), a NARSAD Independent Investigator Award (ALG), the Polish Ministry of Science and Higher Education (N N303 569939, AB and ALG); The National Science Centre (Poland) (DEC-2012/05/D/NZ4/02984, AB and ALG) and an EU-funded Exchange Program (FP7-PEOPLE-IRSES PIRSES-GA-2012-318997 NEUREN project, AB and ALG).