Journal article

STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

Shinya Hidano, Louise M Randall, Lucas Dawson, Hans K Dietrich, Christoph Konradt, Peter J Klover, Beena John, Tajie H Harris, Qun Fang, Bradley Turek, Takashi Kobayashi, Lothar Hennighausen, Daniel P Beiting, Anita A Koshy, Christopher A Hunter

MBIO | AMER SOC MICROBIOLOGY | Published : 2016

Abstract

The local production of gamma interferon (IFN-γ) is important to control Toxoplasma gondii in the brain, but the basis for these protective effects is not fully understood. The studies presented here reveal that the ability of IFN-γ to inhibit parasite replication in astrocytes in vitro is dependent on signal transducer and activator of transcription 1 (STAT1) and that mice that specifically lack STAT1 in astrocytes are unable to limit parasite replication in the central nervous system (CNS). This susceptibility is associated with a loss of antimicrobial pathways and increased cyst formation in astrocytes. These results identify a critical role for astrocytes in limiting the replication of a..

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University of Melbourne Researchers

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Awarded by NIH


Awarded by NATIONAL EYE INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

This work was supported by the Commonwealth of Pennsylvania, a Fellowship from Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation (S.H.), NIH grants AI41158 and 5R21EY021314 (C.A.H.), and the Deutsche Forschungsgemeinschaft (C.K.). L.H. and P.J.K. were supported by the IRP of the NIDDK/NIH, while A.A.K. was supported by NIH NS65116.