Journal article
Baseline and post prophylactic tubal-ovarian surgery CA125 levels in BRCA1 and BRCA2 mutation carriers
Y Chen, E Bancroft, S Ashley, A Arden-Jones, S Thomas, S Shanley, S Saya, E Wakeling, R Eeles, I Locke, J Barwell, L Walker, G Mitchell, A Mitra, S Jhavar, F Lennard, Z Kote-Jarai, R Houlston, N Rahman, H Dorkins Show all
Familial Cancer | SPRINGER | Published : 2014
Abstract
The aim of this study was to determine whether BRCA1 and BRCA2 mutation carriers have different baseline CA125 levels compared with non-carriers, and whether a significant difference in pre- and post-operative CA125 levels exists in BRCA mutation carriers undergoing risk-reducing bilateral salpingo-oophorectomy (RRBSO). The study also considered whether CA125 measurements should continue in unaffected BRCA mutation carriers after RRBSO. 383 Eligible women were identified through retrospective review of the BRCA Carrier Clinic at The Royal Marsden NHS Foundation Trust, London, UK. These women all had CA125 levels measured as they were either a carrier or at risk of a BRCA1 or BRCA2 mutation. ..
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Awarded by Manchester Biomedical Research Centre
Funding Acknowledgements
We acknowledge support from Cancer Research UK Grant C5047/A7357 and are grateful for the support of NIHR funding to the NIHR Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust.