The Y1 receptor for NPY: A key modulator of the adaptive immune system

Abstract

Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immune system. The use of Y1 receptor-deficient mice, combined with advanced methods to investigate immune functions, have provided the solution to the problem raised by previous disparities. From results obtained using Y1-deficient mice (Y1- / -), we uncovered a bimodal role for Y1 on immune cells. Y1 expression on antigen-presenting cells (APC) is essential for their function as T..