Journal article

TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts

Claudia Bossen, Teresa G Cachero, Aubry Tardivel, Karine Ingold, Laure Willen, Max Dobles, Martin L Scott, Aris Maquelin, Elodie Belnoue, Claire-Anne Siegrist, Stephane Chevrier, Hans Acha-Orbea, Helen Leung, Fabienne Mackay, Jurg Tschopp, Pascal Schneider

BLOOD | AMER SOC HEMATOLOGY | Published : 2008

Abstract

The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF (BAFF 3-mer) were compared with those of higher-order BAFF oligomers. All forms of BAFF bound BAFF-R and TACI, and elicited BAFF-R-dependent signals in primary B cells. In contrast, signaling through TACI in mature B cells or plasmablasts was only achieved by higher-order BAFF and APRIL oligomers, all of which were also po-tent activators of a multimerization-dependent reporter signaling pathway. These results indicate that, although BAFF-R and TACI can provide B cells with similar signals, only BAFF-R, but not TACI, can resp..

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University of Melbourne Researchers