Journal article

COEXPRESSION OF SOMATOSTATIN SSTR-3 AND SSTR-4 RECEPTOR MESSENGER-RNAS IN THE RAT-BRAIN

J PEREZ, D HOYER

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 1995

Abstract

In situ hybridization histochemistry was used to study the distribution and possible co-expression of the messenger RNA of the somatostatin receptor subtypes SSTR-4 and SSTR-3 in rat brain. Our results demonstrate that SSTR-3 messenger RNA is widely expressed within the rat brain, while expression of SSTR-4 messenger RNA is restricted to the telencephalon, diencephalon and granular layer of the cerebellum. It is also shown that single neurons can co-express both SSTR-4 and SSTR-3 receptor messenger RNAs. The highest density of SSTR-4 messenger RNA was found in the pyramidal cell layer of the hippocampus, especially in the CA1 and CA2 areas, anterior olfactory nuclei, amygdala, and in layers ..

View full abstract

University of Melbourne Researchers