Journal article

5-HYDROXYTRYPTAMINE-1 RECOGNITION SITES IN RAT-BRAIN - HETEROGENEITY OF NON-5-HYDROXYTRYPTAMINE-1A/1C BINDING-SITES REVEALED BY QUANTITATIVE RECEPTOR AUTORADIOGRAPHY

AT BRUINVELS, JM PALACIOS, D HOYER

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 1993

Abstract

Quantitative in vitro receptor autoradiography was used to characterize the [3H]5-hydroxytryptamine binding sites which are not sensitive to 8-hydroxy-2-(di-N-propylamino)tetralin, mesulergine and serotonin-5-O-carboxy-methyl-glycyl-tyrosinamide, in a non-5-hydroxytryptamine1A/1B/1C/1D receptor population, in rat brain. Displacement of [3H]5-hydroxytryptamine [in the presence of 100 nM 8-hydroxy-2-(di-N-propyl-amino)tetralin and mesulergine, to block 5-hydroxytryptamine1A and 5-hydroxytryptamine1C sites] with (-)pindolol, 5-hydroxy-3(4-1,2,5,6-tetrahydropyridyl)-4-azaindole, sumatriptan and serotonin-5-O-carboxy-methyl-glycyl-tyrosinamide yielded complex competition curves suggesting the pre..

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