Synthesis and biological evaluation of a cyclo-beta-tetrapeptide as a somatostatin analogue
K Gademann, M Ernst, D Hoyer, D Seebach
Angewandte Chemie International Edition | WILEY-V C H VERLAG GMBH | Published : 1999
Short β-peptides can mimic natural peptide hormones, as has been shown with a cyclo-β-tetrapeptide (1) that displays micromolar affinity to human somatostatin receptors. β-Peptides are thus a promising new class of peptidomimetics with potential high bioavailability due to their excellent resistance against proteases.