Journal article
Evidence for the presence of 5-HT1B receptor messenger RNA in neurons of the rat trigeminal ganglia
AT Bruinvels, B Landwehrmeyer, MA Moskowitz, D Hoyer
European Journal of Pharmacology Molecular Pharmacology | ELSEVIER SCIENCE BV | Published : 1992
Abstract
In situ hybridization histochemistry and receptor autoradiography were used to determine the presence of 5-HT1B receptor messenger RNA (mRNA) and 5-HT1B receptor proteins, respectively, in rat trigeminal ganglia. Receptor autoradiography on rat trigeminal ganglia, using appropriate 5-HT1B radioligands, did not demonstrate any specific labelling. In contrast, in situ hybridization showed that many ganglion cells contain 5-HT1B receptor mRNA, suggesting the presence of presynaptic 5-HT1B receptors on trigeminovascular neurons. © 1992.