Journal article

MESULERGINE, A SELECTIVE SEROTONIN-2 LIGAND IN THE RAT CORTEX, DOES NOT LABEL THESE RECEPTORS IN PORCINE AND HUMAN CORTEX - EVIDENCE FOR SPECIES-DIFFERENCES IN BRAIN SEROTONIN-2 RECEPTORS

A PAZOS, D HOYER, JM PALACIOS

European Journal of Pharmacology | ELSEVIER SCIENCE BV | Published : 1984

Abstract

The kinetic and pharmacological characteristics of the binding of [3H]ketanserin and [3H]mesulergine to frontal cortical brain membranes from rat, pig and human were studied. In the 3 species [3H]ketanserin labeled sites with the characteristics of the 5-HT2 receptors previously described in the rat. In contrast, [3H]mesulergine labeled 5-HT2 receptors in rat, but not in pig and human cortices. The characteristics of the sites labeled by [3H]mesulergine in pig cortex were similar to those of sites in the choroid plexus of rats, pigs and humans. While several reputed 5-HT2 ligands presented a similar affinity for the [3H]ketanserin binding sites in the 3 species, other such ligands, e.g. mesu..

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