Journal article

CHARACTERIZATION OF SOMATOSTATIN RECEPTOR SUBTYPES

C BRUNS, G WECKBECKER, F RAULF, H LUBBERT, D HOYER, DJ Chadwick (ed.), G Cardew (ed.)

Ciba Foundation symposium | JOHN WILEY & SONS LTD | Published : 1995

Abstract

Somatostatin regulates endocrine and exocrine secretion, possesses antiproliferative properties and acts as a neurotransmitter/neuromodulator in the central nervous system. These effects are mediated by G protein-coupled receptors, of which at least five types have been cloned (sstr1-5). In radioligand-binding studies we have compared the binding properties of sstr1-5 with their activities as somatostatin receptors. All receptors identified so far bind somatostatin-14 and somatostatin-28 with high affinity. The similarities in receptor sequence and in the binding profiles of short synthetic somatostastin analogues such as octreotide, MK 678 or RC 160 for sstr1-5 indicate the existence of two..

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University of Melbourne Researchers