Journal article

INTERNATIONAL UNION OF PHARMACOLOGY CLASSIFICATION OF RECEPTORS FOR 5-HYDROXYTRYPTAMINE (SEROTONIN)

D HOYER, DE CLARKE, JR FOZARD, PR HARTIG, GR MARTIN, EJ MYLECHARANE, PR SAXENA, PPA HUMPHREY

Pharmacological Reviews | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | Published : 1994

Abstract

It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics. This derives from two main research approaches, operational pharmacology, using selective ligands (both agonists and antagonists), and, more recently, molecular biology. Although the scientific community continues to deliberate about the hierarchy of criteria for neurotransmitter receptor characterisation, there seems good agreement between the two approaches regarding 5-HT receptor classification. In addition, the information regarding transduction mechanisms and second messengers is also entirely consistent. Thus, on the ba..

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