NOX2 Complex-Derived ROS as Immune Regulators
Outi Sareila, Tiina Kelkka, Angela Pizzolla, Malin Hultqvist, Rikard Holmdahl
ANTIOXIDANTS & REDOX SIGNALING | MARY ANN LIEBERT, INC | Published : 2011
Reactive oxygen species (ROS) are a heterogeneous group of highly reactive molecules that oxidize targets in a biologic system. During steady-state conditions, ROS are constantly produced in the electron-transport chain during cellular respiration and by various constitutively active oxidases. ROS production can also be induced by activation of the phagocyte NADPH oxidase 2 (NOX2) complex in a process generally referred to as an oxidative burst. The induced ROS have long been considered proinflammatory, causing cell and tissue destruction. Recent findings have challenged this inflammatory role of ROS, and today, ROS are also known to regulate immune responses and cell proliferation and to de..View full abstract
Awarded by EU
This work was supported by the Finnish Academy, Sigrid Juselius Foundation, Nordic Center of Excellence in Disease Genetics, the Swedish Research Council, and the EU project Masterswitch HEALTH-F2-2008-223404.