Journal article

Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors

Tiina Kelkka, Angela Pizzolla, Juha Petteri Laurila, Tomas Friman, Renata Gustafsson, Eva Kallberg, Olof Olsson, Tomas Leanderson, Kristofer Rubin, Marko Salmi, Sirpa Jalkanen, Rikard Holmdahl

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013

Abstract

The NADPH oxidase 2 (NOX2) complex is a professional producer of reactive oxygen species (ROS) and is mainly expressed in phagocytes. While the activity of the NOX2 complex is essential for immunity against pathogens and protection against autoimmunity, its role in the development of malignant tumors remains unclear. We compared wild type and Ncf1 (m1J) mutated mice, which lack functional NOX2 complex, in four different tumor models. Ncf1 (m1J) mutated mice developed significantly smaller tumors in two melanoma models in which B16 melanoma cells expressing a hematopoietic growth factor FLT3L or luciferase reporter were used. Ncf1 (m1J) mutated mice developed significantly fewer Lewis Lung Ca..

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Grants

Awarded by EU Masterswitch


Funding Acknowledgements

This study was supported by grants from the Swedish Strategic Science Foundation, Knut and Alice Wallenberg foundation, Swedish Research Council, Swedish Rheumatism Association, Swedish Cancer Society, The Alfred stelunds Stiftelse (Sweden), Juselius Foundation, Finnish Academy, the Finnish Cancer Foundation, Svenska Kulturfonden in Finland, EU Masterswitch (Grant No. HEALTH-F2-2008-223404), Neurinox and BeTheCure grants. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript