Journal article
5-HT1C receptor-mediated stimulation of inositol phosphate production in pig choroid plexus: A pharmacological characterization
D Hoyer, C Waeber, P Schoeffter, JM Palacios, A Dravid
Naunyn Schmiedeberg S Archives of Pharmacology | SPRINGER | Published : 1989
DOI: 10.1007/BF00173573
Abstract
1) 5-HT (5-hydroxytryptamine, serotonin) induces inositol phosphate production in a pig choroid plexus preparation. This effect has been pharmacologically characterized and the data compared to those obtained from radioligand binding studies performed with [3H]mesulergine to 5-HT1C sites in pig choroid plexus membranes. 2) The rank order of potency of agonists stimulating inositol phosphate production was: α-methyl-5-HT > 1-methyl-5-HT > DOI > bufotenine = SKF 83566 = 5-HT > 5-MeO-DMT > 5-MeOT = RU 24969> SCH 23390> 5-CT. 8-OH-DPAT was virtually devoid of activity at 100 μmol/l. 3) The increase in inositol phosphate production induced by 5-HT and other agonists was surmountably antagonised b..
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