Journal article
5.HT1 receptors in the vertebrate brain: Regional distribution examined by autoradiography
C Waeber, MM Died, D Hoyer, JM Palacios
Naunyn Schmiedeberg S Archives of Pharmacology | SPRINGER | Published : 1989
DOI: 10.1007/BF00260602
Abstract
The regional distribution of high affinity [33H]5-HT recognition sites in the brain of several vertebrates (pigeon, rat, mouse, guinea-pig, cat, dog, monkey and human) was analyzed using in vitro autoradiography. The presence of subtypes of 5-HT1 binding sites was investigated by selective displacements with 8-OH-DPAT, mesulergine and (±)SDZ 21-009 at appropriate concentrations to block 5-HT1A, 5-HT1c and 5-HT1B sites respectively. In addition, 5-HT1A, and 5-HT1c sites were directly visualized with the more selective radioligands [3H]8-OH-DPAT and [3H]mesulergine, respectively. In the pigeon brain, total [3H]5-HT binding sites were enriched in all telencephalic areas. Densely labelled region..
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