Journal article

THE PHARMACOLOGICAL PROPERTIES OF THE PRESYNAPTIC SEROTONIN AUTORECEPTOR IN THE PIG BRAIN CORTEX CONFORM TO THE 5-HT1D RECEPTOR SUBTYPE

E SCHLICKER, K FINK, M GOTHERT, D HOYER, G MOLDERINGS, I ROSCHKE, P SCHOEFFTER

Naunyn-Schmiedeberg's Archives of Pharmacology | SPRINGER VERLAG | Published : 1989

Abstract

The effects of serotonin receptor agonists and antagonists on the electrically (3 Hz) evoked 3H overflow were determined on pig brain cortex slices preincubated with 3H-serotonin and superfused with physiological salt solution containing indalpine (an inhibitor of serotonin uptake) plus phentolamine. The potencies of the serotonin receptor agonists and antagonists were compared with their affinities for 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1D binding sites in pig or rat tissue membranes; in addition, the potencies of the agonists were compared to their potencies in inhibiting adenylate cyclase activity in membranes of calf substantia nigra. In the superfusion experiments on pig brain cortex slice..

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