Journal article

Reactive Oxygen Species Produced by the NADPH Oxidase 2 Complex in Monocytes Protect Mice from Bacterial Infections

Angela Pizzolla, Malin Hultqvist, Bo Nilson, Melissa J Grimm, Tove Eneljung, Ing-Marie Jonsson, Margareta Verdrengh, Tiina Kelkka, Inger Gjertsson, Brahm H Segal, Rikard Holmdahl

The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2012

Abstract

Chronic granulomatous disease (CGD) is an inherited disorder characterized by recurrent life-threatening bacterial and fungal infections. CGD results from defective production of reactive oxygen species by phagocytes caused by mutations in genes encoding the NADPH oxidase 2 (NOX2) complex subunits. Mice with a spontaneous mutation in Ncf1, which encodes the NCF1 (p47(phox)) subunit of NOX2, have defective phagocyte NOX2 activity. These mice occasionally develop local spontaneous infections by Staphylococcus xylosus or by the common CGD pathogen Staphylococcus aureus. Ncf1 mutant mice were more susceptible to systemic challenge with these bacteria than were wild-type mice. Transgenic Ncf1 mut..

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Awarded by European Union


Awarded by National Institute of Allergy and Infectious Diseases


Awarded by National Cancer Institute Cancer Center


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by the Swedish Research Council, the Swedish Strategic Science Foundation, the Academy of Finland, European Union grants BeTheCure and Masterswitch (HEALTH-F2-2008-223404), National Institute of Allergy and Infectious Diseases Grant R01 AI079253 (to B.H.S.), and a National Cancer Institute Cancer Center support grant to Roswell Park Cancer Institute (Grant CA016056).