Cutaneous Na Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense

Jonathan Jantsch; Valentin Schatz; Diana Friedrich; Agnes Schroeder; Christoph Kopp; Isabel Siegert; Andreas Maronna; David Wendelborn; Peter Linz; Katrina J Binger; Matthias Gebhardt; Matthias Heinig; Patrick Neubert; Fabian Fischer; Stefan Teufel; Jean-Pierre David; Clemens Neufert; Alexander Cavallaro; Natalia Rakova; Christoph Kueper; Franz-Xaver Beck; Wolfgang Neuhofer; Dominik N Muller; Gerold Schuler; Michael Uder; Christian Bogdan; Friedrich C Luft; Jens Titze

Journal article

Cutaneous Na Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense

Jonathan Jantsch, Valentin Schatz, Diana Friedrich, Agnes Schroeder, Christoph Kopp, Isabel Siegert, Andreas Maronna, David Wendelborn, Peter Linz, Katrina J Binger, Matthias Gebhardt, Matthias Heinig, Patrick Neubert, Fabian Fischer, Stefan Teufel, Jean-Pierre David, Clemens Neufert, Alexander Cavallaro, Natalia Rakova, Christoph Kueper Show all

Cell Metabolism | CELL PRESS | Published : 2015

DOI: 10.1016/j.cmet.2015.02.003

University of Melbourne Researchers

Katrina Binger Author Biochemistry and Molecular Biology

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It is thought that a protein known as the (pro)renin receptor may cause cardiovascular disease, however little is known about its role in no..

Grants

Awarded by Deutsche Forschungsgemeinschaft (DFG)

Awarded by German Ministry for Economics and Technology

Awarded by NIH

Awarded by American Heart Association

Awarded by IZKF Erlangen

Awarded by Australian National Health and Medical Research Council

Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Funding Acknowledgements

The Deutsche Forschungsgemeinschaft (DFG; SFB 643 A6 and B16; DA1067/7-2) supported J.J., J.P.D., C.B., and J.T. J.T. was also supported by the German Ministry for Economics and Technology (50WB1218), the Interdisciplinary Center for Clinical Research (IZKF) Erlangen, the NIH (RO1 HL118579-01), and the American Heart Association (AHA 14SFRN20770008). C.B. was also supported by the IZKF Erlangen (A61) and the Emerging Field Initiative of the FAU. K.J.B. received an Australian National Health and Medical Research Council C.J. Martin Fellowship (APP1037633). The DFG and the German Center for Cardiovascular Research supported D.N.M. and F.C.L. We thank the Imaging Science Institute (Erlangen) for measurement time and for technical support. We are grateful for the excellent technical assistance of Kirstin Castiglione, Andrea Debus, Heidi Sebald, Jenny Hahnel, Sabrina Cabric, Anna Birukov, Monika Nowottny, and Daniela Amslinger.