Journal article

NEURAMINIC ACID-SPECIFIC LECTINS AS MARKERS OF EARLY CORTICAL PLATE NEURONS

E ADAM, KM DZIEGIELEWSKA, NR SAUNDERS, U SCHUMACHER

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 1993

Abstract

Early cortical plate and subplate cells in the developing neocortex of many animal species and humans contain one specific plasma protein, fetuin. Fetuin is heavily glycosylated and it is possible that due to the large amount of sugars, this molecule may play a part in cellular recognition during brain development. Cellular and extracellular carbohydrates in the developing brain of the sheep were studied histochemically using a battery of fluorescein-labelled lectins. Two neuraminic acid specific lectins, Sambucus nigra and Maackia amurensis, labelled consistently the fetuin-positive cells as demonstrated by double labelling with lectins and antifetuin antibodies. Brain sections from other s..

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