Journal article

Acute-phase cytokines IL-1 beta and TNF-alpha in brain development

KM Dziegielewska, JE Moller, AM Potter, J Ek, MA Lane, NR Saunders

Cell and Tissue Research | SPRINGER | Published : 2000


The nervous and the immune systems share several molecules that control their development and function. We studied the temporal and spatial distribution of the immunoreactivity of two acute-phase cytokines, TNF-alpha and IL-1beta, in the developing sheep neocortex and compared it with the well-described distribution of fetuin, a fetal glycoprotein also known to modulate the production of cytokines by lipopolysaccharide (LPS)-stimulated monocytes and macrophages. TNF-alpha was present first at embryonic day 30 (E30) (term is 150 days in sheep) as a faint band of immunoreactivity between the ventricular zone and the primordial plexiform layer (preplate). IL-1beta was detected at the first appe..

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