Journal article

A FETUIN-RELATED GLYCOPROTEIN (ALPHA-2HS) IN HUMAN-EMBRYONIC AND FETAL DEVELOPMENT

KM DZIEGIELEWSKA, K MOLLGARD, ML REYNOLDS, NR SAUNDERS

CELL AND TISSUE RESEARCH | SPRINGER VERLAG | Published : 1987

Abstract

The human plasma protein, alpha 2HS glycoprotein, has an amino acid composition very similar to that of fetuin, the major protein in fetal calf and lamb serum. Immunohistochemical studies of human fetuses (6-33 weeks gestation) showed that alpha 2HS glycoprotein and fetuin have similar distributions in developing brain and several other tissues, e.g., bone, kidney, gonads, gastrointestinal tract, respiratory and cardiovascular systems. There were notable differences in the liver and thymus in the distribution of the two proteins. Fetuin and alpha 2HS glycoprotein are present in plasma and cerebrospinal fluid of both human and sheep fetuses; their concentrations are reciprocally related: in h..

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