Journal article

FETUIN - AN OLD FRIEND REVISITED

WM BROWN, NR SAUNDERS, K MOLLGARD, KM DZIEGIELEWSKA

BioEssays | WILEY | Published : 1992

Abstract

Bovine fetuin, the first fetal protein to be described, has recently been shown to be a species homologue of a well known human plasma protein--alpha 2HS glycoprotein (alpha 2HS). The fetuins are now known to be members of the cystatin superfamily. The structural properties of the six fetuins that have been fully sequenced are compared. Despite the structural homology of these proteins, their described properties in the literature make them appear to be quite different. The diverse in vitro properties claimed for fetuin/alpha 2HS are reviewed. In vivo, fetuins are involved in the acute phase response. In development, in all species studied so far, fetuins are present in a specific cell popul..

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