Journal article

DEVELOPMENT OF A BLOOD-BRAIN-BARRIER MECHANISM IN FETAL SHEEP

CAN EVANS, JM REYNOLDS, ML REYNOLDS, NR SAUNDERS, MB SEGAL

JOURNAL OF PHYSIOLOGY-LONDON | WILEY-BLACKWELL | Published : 1974

Abstract

1. The penetration of a metabolically inert, small molecular radius lipid insoluble substance ([(13)C] and [(4)H]sucrose), from blood into brain and c.s.f., has been studied in developing sheep from 50 days gestation (term, 150 days) through to the new-born stage. Around 50 days gestation sucrose accumulated rapidly into brain and c.s.f., and reached a steady-state level in brain of about 12% of the plasma level by 3 hr. By 60 days sucrose penetrated less freely into brain and c.s.f.; the brain steady-state level was 10% by 4(1/2) hr. A large decrease in sucrose penetration occurred by 70 days gestation, and by 123 days (just before the time when a foetal lamb becomes viable) both the rate o..

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