Journal article

INVITRO AUTORADIOGRAPHIC LOCALIZATION OF BINDING TO ANGIOTENSIN RECEPTORS IN THE RAT-HEART

AM ALLEN, H YAMADA, FAO MENDELSOHN

INTERNATIONAL JOURNAL OF CARDIOLOGY | ELSEVIER SCI IRELAND LTD | Published : 1990

Abstract

The distribution of binding to angiotensin II receptors in the rat heart was determined by quantitative in vitro autoradiography employing 125I-[Sar1, Ile8] angiotensin II as the radioligand. Low density binding occurs in the myocardium of both the atriums and ventricles and in the media of the aorta, pulmonary arteries and superior caval vein. Dense punctate binding is found over parasympathetic nerve bundles and some cells of the intracardiac ganglions. Binding is very low in nerves which do not stain for acetylcholinesterase. A moderate to high density of binding sites occurs throughout the conduction system, including the sinus node (low), the atrioventricular node (high) and the atriove..

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