Journal article

VIRUS-SPECIFIC CD8 T-CELL MEMORY DETERMINED BY CLONAL BURST SIZE

S HOU, L HYLAND, KW RYAN, A PORTNER, PC DOHERTY

NATURE | NATURE PUBLISHING GROUP | Published : 1994

Abstract

Although some viruses, particularly the herpes viruses, may never be eliminated from the body, others like influenza A, regularly reinfect humans and boost waning crossreactive CD8+ T-cell immunity. Prolonged T-cell memory is found for viruses that are unlikely to be re-encountered and which do not persist in the host genome, indicating that CD8+ T-cell memory might be independent of continued (or sporadic) antigenic exposure. A feature of virus-specific CD8+ T-cell memory is that antigen-specific cytotoxic T-lymphocyte precursors (CTLp) are greatly increased and remain high throughout life. The idea that persistence of the inducing antigen is essential is based on experiments in which adopt..

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University of Melbourne Researchers