Journal article

LIMITING THE AVAILABLE T-CELL RECEPTOR REPERTOIRE MODIFIES ACUTE LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INDUCED IMMUNOPATHOLOGY

PC DOHERTY, S HOU, CF EVANS, JL WHITTON, MBA OLDSTONE, MA BLACKMAN

JOURNAL OF NEUROIMMUNOLOGY | ELSEVIER SCIENCE BV | Published : 1994

Abstract

The invariably fatal immunopathological disease that follows intracerebral injection of CBA/Ca (H-2k) mice with 1000 PFU of lymphocytic choriomeningitis virus (LCMV) generally fails to develop in congenic mice transgenic for a V beta 8.1D beta 2J beta 2.3C beta 2 T cell receptor (TCR) gene. The majority of these LCMV-infected TCR-transgenic mice show a substantial meningitis of delayed onset, that resolves without causing any obvious clinical impairment. This inflammatory process depends on the involvement of V beta 8+ T cells, but does not require the participation of the CD4+ subset. The cytotoxic effectors that develop in both the transgenic mice and the CBA/Ca controls are lytic for targ..

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University of Melbourne Researchers