Journal article

EXPRESSION OF PGP-1 (OR LY24) BY SUBPOPULATIONS OF MOUSE THYMOCYTES AND ACTIVATED PERIPHERAL LYMPHOCYTES-T

F LYNCH, G CHAUDHRI, JE ALLAN, PC DOHERTY, R CEREDIG

EUROPEAN JOURNAL OF IMMUNOLOGY | VCH PUBLISHERS INC | Published : 1987

Abstract

The expression of Pgp-1 (Ly24) by subpopulations of thymocytes was investigated and a subpopulation of Lyt-2-/L3T4-/J11d- thymocytes was identified which contained significant numbers (80%) of Pgp-1+ cells. Among freshly isolated lymph node T cells but not cortisone-resistant thymocytes, Pgp-1 expression was heterogeneous. Stimulation of T lymphocytes with either concanavalin A or the combination of phorbol myristate acetate plus calcium ionophore resulted in increased Pgp-1 expression which was found to be regulated independently of DNA synthesis and interleukin 2 receptor expression. T cells in the cerebrospinal fluid exudate of mice infected with lymphocytic choriomeningitis virus were al..

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