Expression of Pgp‐1 (or Ly24) by subpopulations of mouse thymocytes and activated peripheral T lymphocytes

Abstract

The expression of Pgp‐1 (Ly24) by subpopulations of thymocytes was investigated and a subpopulation of Lyt‐2−/L3T4−/J11d− thymocytes was identified which contained significant numbers (80%) of Pgp‐1+ cells. Among freshly isolated lymph node T cells but not cortisone‐resistant thymocytes, Pgp‐1 expression was heterogeneous. Stimulation of T lymphocytes with either concanavalin A or the combination of phorbol myristate acetate plus calcium ionophore resulted in increased Pgp‐1 expression which was found to be regulated independently of DNA synthesis and interleukin 2 receptor expression. T cells in the cerebrospinal fluid exudate of mice infected with lymphocytic choriomeningitis virus were al..