Journal article

CONTRIBUTIONS OF HOST AND DONOR T-CELLS TO THE INFLAMMATORY PROCESS IN MURINE LYMPHOCYTIC CHORIOMENINGITIS

PC DOHERTY, JE ALLAN, R CEREDIG

CELLULAR IMMUNOLOGY | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1988

Abstract

The severe inflammation characteristic of the infection of adult mice with murine lymphocytic choriomeningitis virus (LCMV) is induced earlier in unsuppressed, virus-infected recipients by the adoptive transfer of class I MHC-compatible, CD4- CD8+ LCMV-immune spleen cell populations. The time to onset of fatal LCM may also be slightly diminished, though not to the extent that would be expected from the enhanced kinetics of the extravasation of cells into cerebrospinal fluid. The development of symptoms is thus not solely related to the magnitude of the inflammatory process. The majority of the T lymphocytes in the inflammatory exudate are of host origin and have the size characteristics of r..

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University of Melbourne Researchers