The response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment

Abstract

Immunologically naive C57BL/6J(B6, H-2KbDb) T cells can, after negative selection in vivo to remove alloreactive lymphocytes, be induced to respond to H-2Kk-vaccinia virus when primed in irradiated B10.A(4R) (H-2KkDb) recipients. Precursors with the capacity to generate cytotoxic T-lymphocyte (CTL) effector function specific for H-2Kk-vaccinia virus are present in the long-lived, recirculating T-cell pool. However, prior priming of the B6(H-2b) mice with vaccinia virus abrogates the responder potential of the H-2b CTL for H-2Kk-vaccinia virus. Furthermore, addition of primed to unprimed H-2b T cells greatly diminishes the response of the naive lymphocyte populations. A possible mechanism for..