Journal article

Diminished primary and secondary influenza virus-specific CD8( ) T-cell responses in CD4-depleted Ig(-/-) mice

JM Riberdy, JP Christensen, K Branum, PC Doherty

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2000

Abstract

Optimal expansion of influenza virus nucleoprotein (D(b)NP(366))-specific CD8(+) T cells following respiratory challenge of naive Ig(-/-) microMT mice was found to require CD4(+) T-cell help, and this effect was also observed in primed animals. Absence of the CD4(+) population was consistently correlated with diminished recruitment of virus-specific CD8(+) T cells to the infected lung, delayed virus clearance, and increased morbidity. The splenic CD8(+) set generated during the recall response in Ig(-/-) mice primed at least 6 months previously showed a normal profile of gamma interferon production subsequent to short-term, in vitro stimulation with viral peptide, irrespective of a concurren..

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University of Melbourne Researchers