Journal article

CONSEQUENCES OF A SINGLE IR-GENE DEFECT FOR THE PATHOGENESIS OF LYMPHOCYTIC CHORIOMENINGITIS

JE ALLAN, PC DOHERTY

IMMUNOGENETICS | SPRINGER VERLAG | Published : 1985

Abstract

The H-2Ld allele has been identified by others as the sole Ir gene in the H-2d haplotype for the cytotoxic T lymphocyte (CTL) response to mouse lymphocytic choriomeningitis virus (LCMV). The BALB/c-H-2dm2 (C-H-2dm2) mutant lacks H-2Ld, and thus should be ideal for assessing the contribution of virus-immune CTL to LCM immunopathology. Comparison of the C-H-2dm2 mice with congenic BALB/c mice revealed that there is a delay of about 24 h in the onset of severe inflammatory process and symptoms in the mutant strain, but the absence of H-2Ld did not prevent the later development of fatal disease in mice injected intracerebrally (i.c.) with neurotropic LCMV. This could indicate that virus-immune C..

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University of Melbourne Researchers