Journal article

ISOLATION OF VIRUS FROM BRAIN AFTER IMMUNOSUPPRESSION OF MICE WITH LATENT HERPES-SIMPLEX

L KASTRUKOFF, C LONG, PC DOHERTY, Z WROBLEWSKA, H KOPROWSKI

NATURE | MACMILLAN MAGAZINES LTD | Published : 1981

Abstract

Herpes simplex virus (HSV) is usually present in a latent form in the trigeminal ganglion of an1-3. Various stress factors may induce virus reactivation, which is manifest by a lip lesion (innervated from the trigeminal ganglion) and the production of infectious virus. The considerable experimental efforts to define the conditions that lead to the reactivation of latent HSV have concentrated on isolating virus either from the original extraneural site of virus inoculation, or from cell-free homogenates of sensory ganglia from latently infected animals4-15. Recent DNA hybridization experiments resulted in the demonstration of the presence of HSV genomes in the brain tissue of both latently in..

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University of Melbourne Researchers