EFFECTS OF 4 H-2K MUTATIONS ON VIRUS-INDUCED ANTIGENS RECOGNIZED BY CYTOTOXIC-T CELLS

Abstract

Lysis of ectromelia- or LCM virus-infected macrophage target cells by virus-specific cytotoxic T cells from mice immunized with the homologous virus occurred only where donors of T cells and target cells shared either H-2K or H-2D genes. With both viruses, use of T cell or target cell donors bearing mutations (B6.C-H-2ba, B6-H-2bh, B6-H-2bg1, and B6-H-2bg2), all of which apparently occurred in the same single genetic element in the H-2Kb region, abolished (H-2ba) or impaired (H-2bh, H-2bg1 and H-2bg2) lysis in T cell-target cell combinations that shared (apart from the mutations) all other genes in the K, I-A, or I-B regions of the H-2 complex. The data suggest that virus-induced antigenic p..